20.500.12556/RUL-129637 Low water activity induces the production of bioactive metabolites in halophilic and halotolerant fungi The aim of the present study was to investigate indigenous fungal communities isolated from extreme environments (hypersaline waters of solar salterns and subglacial ice), for the production of metabolic compounds with selected biological activities: hemolysis, antibacterial, and acetylcholinesterase inhibition. In their natural habitats, the selected fungi are exposed to environmental extremes, and therefore the production of bioactive metabolites was tested under both standard growth conditions for mesophilic microorganisms, and at high NaCl and sugar concentrations and low growth temperatures. The results indicate that selected halotolerant and halophilic species synthesize specific bioactive metabolites under conditions that represent stress for non-adapted species. Furthermore, adaptation at the level of the chemical nature of the solute lowering the water activity of the medium was observed. Increased salt concentrations resulted in higher hemolytic activity, particularly within species dominating the salterns. The appearance of antibacterial potential under stress conditions was seen in the similar pattern of fungal species as for hemolysis. The active extracts exclusively affected the growth of the Gram-positive bacterium tested, Bacillus subtilis. None of the extracts tested showed inhibition of acetylcholinesterase activity. hypersaline environments black yeast NaCl secondary metabolites hemolysis antibacterial activity true false true Angleški jezik Ni določen Članek v reviji 2021-09-06 12:37:16 2021-09-06 12:37:17 2022-09-08 04:09:46 0000-00-00 00:00:00 2011 0 0 Str. 43-58 iss. 1 Vol. 9 2011 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.2 1660-3397 10.3390/md9010043 2320719 RAZ_Sepcic_Kristina_2011.pdf RAZ_Sepcic_Kristina_2011.pdf 1 F677E4E5BC2F933FDE58BA9D52A93154 32b46bcde7bca5f70eb8a8a9a6f2c64d6cf996dd7ad0403e679edfb0667e036b 61ccf8ea-0efe-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146653 https://www.mdpi.com/1660-3397/9/1/43 0 5c0f72bd-0efe-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146652 Biotehniška fakulteta 0 0 0