20.500.12556/RUL-129517 Parallel synthesis of 2-substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1–12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic amines 18{1–12} to afford the corresponding carboxamides 10 in good overall yields and in 80–100% purity. parallel synthesis pyrimidines 2-(heteroaryl)ethylamines organska kemija sinteze paralelna sinteza organske reakcije struktura spojin NMR spektri heterociklične spojine heterociklični sistemi heterocikli derivati pirimidina pirimidini derivati amina 2-(heteroaril)etilamini karboksamidi true false true Angleški jezik Slovenski jezik Članek v reviji 2021-09-03 11:51:58 2021-09-03 11:51:59 2022-09-08 04:09:00 0000-00-00 00:00:00 2012 0 0 Str. 5363-5384 iss. 5 Vol. 17 2012 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.853.022.057 1420-3049 10.3390/molecules17055363 35944709 RAZ_Crcek_Bojana_2012.pdf RAZ_Crcek_Bojana_2012.pdf 1 9E723ADCDA1FBE0636D691A9F95EF40D 6334bdf339226ee2d177ab517eb7541563047a5d2c42ddc9eefef36895259e87 986376b9-0c9c-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146516 https://www.mdpi.com/1420-3049/17/5/5363 0 82357e83-0c9c-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146515 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0