20.500.12556/RUL-129513 Renal alterations in feline immunodeficiency virus (FIV)-infected cats a natural model of lentivirus-induced renal disease changes Human immunodeficiency virus (HIV) is associated with several renal syndromes including acute and chronic renal failures, but the underlying pathogenic mechanisms are unclear. HIV and feline immunodeficiency virus (FIV) share numerous biological and pathological features, including renal alterations. We investigated and compared the morphological changes of renal tissue of 51 experimentally and 21 naturally infected cats. Compared to the latter, the experimentally infected cats exhibited some mesangial widening and glomerulonephritis, milder proteinuria, and lower tubular and interstitial alterations. The numbers of giant protein tubular casts and tubular microcysts were also lower. In contrast, diffuse interstitial infiltrates and glomerular and interstitial amyloidosis were detected only in naturally infected cats. Similar alterations are found in HIV infected patients, thus supporting the idea of a causative role of FIV infection in renal disease, and underlining the relevance of the FIV and its natural host as an animal model for investigating lentivirus-associated nephropathy. cat feline immunodeficiency virus FIV kidney diseases renal pathology true false true Angleški jezik Ni določen Članek v reviji 2021-09-03 10:32:42 2021-09-03 10:32:43 2022-09-08 04:08:58 0000-00-00 00:00:00 2012 0 0 Str. 1372-1389 iss. 9 Vol. 4 2012 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616 1999-4915 10.3390/v4091372 3576954 RAZ_Poli_Alessandro_2012.pdf RAZ_Poli_Alessandro_2012.pdf 1 9CEA2118D469C97BF9BEBD8543241A38 c0199759b98d5cfb3f2b2496d0ffebcf22d3907fba4b23e65697af65ea133693 adfc5146-0c91-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146508 https://www.mdpi.com/1999-4915/4/9/1372 0 971eefd7-0c91-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146507 Veterinarska fakulteta 0 0 0