20.500.12556/RUL-129510 Adaptive response, evidence of cross-resistance and its potential clinical use Organisms and their cells are constantly exposed to environmental fluctuations. Among them are stressors, which can induce macromolecular damage that exceeds a set threshold, independent of the underlying cause. Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli. Different stressors or different intensities of stress trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc. These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants. oxidative stress stress adaptation adaptive response preconditioning pretreatment hormesis autophagy apoptosis anti-apoptosis environmental exposure autophagocytosis eukaryotic cells DNA damage DNA repair macromolecular systems antioxidants reactive oxygen species adaptacija avtofagocitoza okoljska izpostavljenost oksidativni stres apoptoza poškodbe DNA antioksidanti evkariontske celice aktivne oblike kisika makromolekularni sistemi obnova DNA true false true Angleški jezik Slovenski jezik Članek v reviji 2021-09-03 08:10:17 2021-09-03 08:10:22 2022-09-08 04:08:57 0000-00-00 00:00:00 2012 0 0 Str. 10771-10806 iss. 9 Vol. 13 2012 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-092 1422-0067 10.3390/ijms130910771 30114777 RAZ_Milisav_Irina_2012.pdf RAZ_Milisav_Irina_2012.pdf 1 5B3F90734BA1EB04105C0A1820B81D90 61032c161098ca07a3bf4781edaa55f29c06fb71f70b16bd0453fbb7f20d0545 8c391447-0c7e-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146501 http://www.mdpi.com/1422-0067/13/9/10771 1 6328af1c-0c7d-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146500 Medicinska fakulteta Zdravstvena fakulteta 0 0 0