20.500.12556/RUL-129027 Bacteriophage delivery systems based on composite polyHIPE/nanocellulose hydrogel particles The role of bacteriophage therapy in medicine has recently regained an important place. Oral phage delivery for gastrointestinal treatment, transport through the stomach, and fast release in the duodenum is one of such applications. In this work, an efficient polyHIPE/hydrogel system for targeted delivery of bacteriophages with rapid release at the target site is presented. T7 bacteriophages were encapsulated in low crosslinked anionic nanocellulose-based hydrogels, which successfully protected phages at pH < 3.9 (stomach) and completely lost the hydrogel network at a pH above 3.9 (duodenum), allowing their release. Hydrogels with entrapped phages were crosslinked within highly porous spherical polyHIPE particles with an average diameter of 24 µm. PolyHIPE scaffold protects the hydrogels from mechanical stimuli during transport, preventing the collapse of the hydrogel structure and the unwanted phage release. On the other hand, small particle size, due to the large surface-to-volume ratio, enables rapid release at the target site. As a consequence, a fast zero-order release was achieved, providing improved patient compliance and reduced frequency of drug administration. The proposed system therefore exhibits significant potential for a targeted drug delivery in medicine and pharmacy. TEMPO nanocellulose T7 bacteriophage encapsulation drug diffusion zero-order release TEMPO nanoceluloza bakteriofag T7 inkapsulacija difuzija učinkovin sproščanje ničtega reda true false true Angleški jezik Slovenski jezik Članek v reviji 2021-08-24 11:14:18 2021-08-24 11:14:19 2022-09-08 04:06:07 0000-00-00 00:00:00 2021 0 0 12 str. iss. 16, art. 2648 Vol. 13 Aug. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 678:615:578.81 2073-4360 10.3390/polym13162648 73830403 RAZ_Kopac_Tilen_2021.pdf RAZ_Kopac_Tilen_2021.pdf 1 3EDA81A81DA19054BE48A0E2A7919333 4e962a04731481dd3e19015c519c46f16e4af95543c67234872286f704645902 93cc3b90-04bc-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145949 https://www.mdpi.com/2073-4360/13/16/2648 0 728c3ad6-04bb-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145946 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0