20.500.12556/RUL-128957 Sinteza oksalata morfolinoetiletra mikofenolat mofetila in študij kinetike njegove hidrolize v kislih in bazičnih pogojih Synthesis of oxalate morpholinoethylether mycophenolate mophetile and study of its hydrolisis kinetics in acidic and alkaline conditions Mikofenolat mofetil je polsintezna zdravilna učinkovina, ki se uporablja za zaviranje imunskega odziva pri presaditvi organov (ledvica, srce, jetra). Za potrebe farmacevtske industrije se uporabljajo različne nečistote kot analitski standardi. V diplomskem delu smo se ukvarjali s sintezo ene izmed nečistot mikofenolat mofetila in sicer oksalatom morfolinoetiletrom mikofenolat mofetilom, ki smo ga v dveh korakih sintetizirali po postopku iz literature. Sintezo smo izvedli tudi na večji skali, kjer smo dobili boljše izkoristke. Eksperimentalni del smo zaključili s hidrolizo sintetizirane spojine pod kislimi (HCl) in bazičnimi (NaOH, LiOH) pogoji. Mycophenolate mofetile is half-synthetic active substance used for suppression of immune response in organ transplantation (kidney, heart, liver). For the purpose of analytic control, specific impurities as analytical standards are needed. In the diploma thesis we dealt with the synthesis of one of the impurities of mycophenolate mofetil, namely oxalate morpholinoethyl ether mycophenolate mofetil, which was synthesized in two steps according to the procedure from the literature. The synthesis was also performed on a larger scale, where we obtained higher yields of the product. The experimental part was completed by hydrolysis of the synthesized compound under acidic (HCl) and basic (NaOH, LiOH) conditions. mikofenolat mofetil nečistota hidroliza sinteza mycophenolate mofetil impurity hydrolysis synthesis true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2021-08-19 09:37:08 2021-08-19 09:37:08 2022-09-07 04:17:50 0000-00-00 00:00:00 2021 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 19241 75002883 Skrekovski_Dimitra_-_Sinteza_oksalata_morfolinoetiletra_mikofenolat_mofetila_in_studij_kinetike_.pdf Skrekovski_Dimitra_-_Sinteza_oksalata_morfolinoetiletra_mikofenolat_mofetila_in_studij_kinetike_.pdf 1 F153B122C03794D6BBA3A7E1B7397652 877c32c25d187dc32758663ebdc4259ab3e68b4c6487bf16025047fc53257449 0cc590b2-00c0-11ec-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145868 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0