20.500.12556/RUL-128789 Circulating RNAs as potential biomarkers in amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a complex multi-system neurodegenerative disorder with currently limited diagnostic and no therapeutic options. Despite the intense efforts no clinically applicable biomarkers for ALS are yet established. Most current research is thus focused, in particular, in identifying potential non-invasive circulating biomarkers for more rapid and accurate diagnosis and monitoring of the disease. In this review, we have focused on messenger RNA (mRNA), non-coding RNAs (lncRNAs), micro RNAs (miRNAs) and circular RNA (circRNAs) as potential biomarkers for ALS in peripheral blood serum, plasma and cells. The most promising miRNAs include miR-206, miR-133b, miR-27a, mi-338-3p, miR-183, miR-451, let-7 and miR-125b. To test clinical potential of this miRNA panel, a useful approach may be to perform such analysis on larger multi-center scale using similar experimental design. However, other types of RNAs (lncRNAs, circRNAs and mRNAs) that, together with miRNAs, represent RNA networks, have not been yet extensively studied in blood samples of patients with ALS. Additional research has to be done in order to find robust circulating biomarkers and therapeutic targets that will distinguish key RNA interactions in specific ALS-types to facilitate diagnosis, predict progression and design therapy. amyotrophic lateral sclerosis ALS circulating biomarkers circulating RNAs blood miRNA IncRNA circRNA mRNA ceRNET amiotrofična lateralna skleroza biomarkerji v obtoku RNA v obtoku kri true false true Angleški jezik Slovenski jezik Članek v reviji 2021-07-29 15:26:00 2021-07-29 15:26:02 2022-09-07 04:17:12 0000-00-00 00:00:00 2020 0 0 21 str. iss. 5, art. 1714 Vol. 21 Mar. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616 1422-0067 10.3390/ijms21051714 34467843 RAZ_Ravnik-Glavac_Metka_2020.pdf RAZ_Ravnik-Glavac_Metka_2020.pdf 1 0DE678FBFCC71BD306A68C70341AEB5F 6df47fa5168bc44a8ee2ccf2c33e448e54684f71e2750b0947e04f3b2b74c47b 5ae4d452-f070-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145671 https://www.mdpi.com/1422-0067/21/5/1714 0 8674e686-f070-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145672 Medicinska fakulteta 0 0 0