20.500.12556/RUL-128786 Uromodulin and microRNAs in kidney transplantation - association with kidney graft function Uromodulin and microRNAs (miRNAs) have recently been investigated as potential biomarkers for kidney graft associated pathology and outcome, with a special focus on biomarkers indicating specific disease processes and kidney graft survival. The study's aim was to determine whether expression of serum uromodulin concentration and selected miRNAs might be related to renal function in kidney transplant recipients (KTRs). The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. Kidney graft function was estimated with routine parameters (creatinine, urea, cystatin C, and Chronic Kidney Disease Epidemiology Collaboration study equations) and precisely measured using chromium-51 labelled ethylenediaminetetraacetic-acid clearance. The selected miRNAs were shown to be independent of kidney graft function, indicating their potential as biomarkers of associated kidney graft disease processes. In contrast, the serum uromodulin level depended entirely on kidney graft function and thus reflected functioning tubules rather than any specific kidney graft injury. However, decreased concentrations of serum uromodulin can be observed in the early course of tubulo interstitial injury, there by suggesting its useful role as an accurate, noninvasive biomarker of early (subclinical) kidney graft injury. microRNA uromodulin kidney graft function biomarker kidney transplantation mikroRNA uromodulin delovanje ledvičnega presadka biološki označevalec presaditev ledvic true false true Angleški jezik Slovenski jezik Članek v reviji 2021-07-29 14:43:14 2021-07-29 14:43:16 2022-09-07 04:17:11 0000-00-00 00:00:00 2020 0 0 11 str. iss. 16, art. 5592 Vol. 21 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.6 1422-0067 10.3390/ijms21165592 24550915 RAZ_Borstnar_Spela_2020.pdf RAZ_Borstnar_Spela_2020.pdf 1 20F9010859283B9FCB6EA73E638C2886 8ac65637befa79bc10812ea0badbcd4ec9869b0efb269c314224dcf4290b526c 617568ad-f06a-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145665 https://www.mdpi.com/1422-0067/21/16/5592 0 8aa55a0b-f06a-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=145666 Medicinska fakulteta 0 0 0