20.500.12556/RUL-128260 Polyphenols from food and natural products neuroprotection and safety Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties. Many studies have highlighted their potential role in the prevention and treatment of various pathological conditions connected to oxidative stress and inflammation (e.g., cancer, and cardiovascular and neurodegenerative disorders). Neurodegenerative diseases are globally one of the main causes of death and represent an enormous burden in terms of human suffering, social distress, and economic costs. Recent data expanded on the initial antioxidant-based mechanism of polyphenols’ action by showing that they are also able to modulate several cell-signaling pathways and mediators. The proposed benefits of polyphenols, either as protective/prophylactic substances or as therapeutic molecules, may be achieved by the consumption of a natural polyphenol-enriched diet, by their use as food supplements, or with formulations as pharmaceutical drugs/nutraceuticals. It has also been proved that the health effects of polyphenols depend on the consumed amount and their bioavailability. However, their overconsumption may raise safety concerns due to the accumulation of high levels of these molecules in the organism, particularly if we consider the loose regulatory legislation regarding the commercialization and use of food supplements. This review addresses the main beneficial effects of food polyphenols, and focuses on neuroprotection and the safety issues related to overconsumption. bioavailability in vitro models neuroprotection neurotoxicity polyphenols toxicity živila fenolne spojine polifenoli bioaktivne snovi nevroprotektivne snovi true false true Angleški jezik Slovenski jezik Članek v reviji 2021-07-07 15:05:57 2021-07-07 15:05:57 2022-09-07 04:14:02 0000-00-00 00:00:00 2020 0 0 13 str. iss. 1, art. 61 Vol. 9 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.9:641.1:547.56:616.8 2076-3921 10.3390/antiox9010061 5147512 RAZ_Silva_Rui_F._M._2020.pdf RAZ_Silva_Rui_F._M._2020.pdf 1 E515184FA02D7D45B0E56192FB35D2E7 4608c3b91298b8fa4d89b40d0d7d785b2900fdeef7a53f7d04fde871d1ce14c4 540ae13c-df24-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=144942 https://www.mdpi.com/2076-3921/9/1/61 0 f046c1c3-df23-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=144941 Biotehniška fakulteta 0 0 0