20.500.12556/RUL-128219 Novi pristopi za oblikovanje peptidov v razvoju biološko aktivnih učinkovin New approaches for peptide design in the development of therapeutics Peptidi, predvsem speti in ciklični, so v zadnjem času vzbudili veliko zanimanja na področju razvoja biološko aktivnih učinkovin. Njihova prednost je majhna velikost, zmožnost prehajanja v celico, hkrati pa tudi visoka selektivnost vezave na tarčno molekulo ter zmožnost vplivanja na interakcije med proteini. Nove tehnologije na področju sintezne biologije omogočajo produkcijo velikih zbirk peptidnih molekul oz. peptidnih knjižnic ter hitro in učinkovito izbiranje peptidov z najboljšo afiniteto vezave na tarčo. Podjetje PeptiDream, katerega tehnologija je podrobneje opisana v tem diplomskem delu, je izpopolnilo pristope pridobivanja in izboljšave pripetih peptidov, njihovi produkti pa vstopajo v klinične študije. Peptides, especially constrained and cyclic peptides, are receiving increasing attention in drug discovery. Their advantages are small size, intracellular activity, as well as high selectivity of binding to the target molecule, and the ability to effect interactions between proteins. New synthetic biology technologies enable the production of large constrained peptide libraries and the rapid and efficient selection of peptides with high target binding affinity. The company PeptiDream, whose technology is described in this diploma work, has already established an effective technology for obtaining and improving constrained peptides, and a number of products are already entering clinical trials. biološke učinkovine aktivne učinkovine peptidi sinteza peptidov pripeti peptidi interakcije med proteini razvoj zdravil biologics active substances peptides peptide synthesis constrained peptides protein interactions drug development true false false [R. Kužnik] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2021-07-07 07:15:02 2021-07-07 07:15:20 2022-09-07 04:13:45 0000-00-00 00:00:00 2021 0 Ljubljana 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 601.2:577.112.6(043.2) 191373 70019843 15311.pdf 15311.pdf 1 E17ADDFB4C95C115B5BF1B79C5572A6E d48a2cd4783737ed9c84914dc87e81c8e421e8db67d700636954b1ca673ef170 31668c97-dee2-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=144884 Biotehniška fakulteta 0 0 0