20.500.12556/RUL-126446 Efficient inactivation of MS-2 virus in water by hydrodynamic cavitation The aim of this study was to accurately quantify the impact of hydrodynamic cavitation on the infectivity of bacteriophage MS2, a norovirus surrogate, and to develop a small scale reactor for testing the effect of hydrodynamic cavitation on human enteric viruses, which cannot be easily prepared in large quantities. For this purpose, 3 mL scale and 1 L scale reactors were constructed and tested. Both devices were efficient in generating hydrodynamic cavitation and in reducing the infectivity of MS2 virus. Furthermore, they reached more than 4 logs reductions of viral infectivity, thus confirming the scalability of hydrodynamic cavitation for this particular application. As for the mechanism of page inactivation, we suspect that cavitation generated OH$^-$ radicals formed an advanced oxidation process, which could have damaged the host's recognition receptors located on the surface of the bacteriophage. Additional damage could arise from the high shear forces inside the cavity. Moreover, the effectiveness of the cavitation was higher for suspensions containing low initial viral titers that are in similar concentration to the ones found in real water samples. According to this, cavitation generators could prove to be a useful tool for treating virus-contaminated wastewaters in the future. MS2 bacteriophage norovirus surrogate hydrodynamic cavitation Venturi type constriction phage infectivity kavitacija MS2 bakteriofag venturijeva cev virusi infektivnost true false true Angleški jezik Slovenski jezik Zapis Sherpa Romeo za revijo Water research https://v2.sherpa.ac.uk/id/publication/13286 : licenca za recenzirani rokopis (Accepted Version) je CC BY-NC-ND 4.0. (Datum opombe: 15. 3. 2023) Članek v reviji 2021-04-22 14:29:48 2021-04-22 14:29:49 2023-03-16 03:33:02 0000-00-00 00:00:00 2017 0 0 Str. 465-471 Vol. 124 Nov. 2017 0000-00-00 PostprintKoncna Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2019-08-08 578.2:532(045) 0043-1354 10.1016/j.watres.2017.07.077 15600923 RAZ_Kosel_Janez_2017.pdf RAZ_Kosel_Janez_2017.pdf 1 4387ABAE51FCFB6B3AF11D1E07BB0C21 2d4bf289763bdb6d00552729b81dbe103238639c30b09efc115787de4de2ec03 d9f1af7c-a366-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=142418 https://www.sciencedirect.com/science/article/pii/S0043135417306504?via%3Dihub 0 6e1a3212-a366-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=142417 Fakulteta za strojništvo 0 0 0