20.500.12556/RUL-125378 Designing homogeneous copper-free Sonogashira reaction through a prism of Pd-Pd transmetalation Simultaneous introduction of two different palladium (pre)catalysts, one tuned to promote oxidative addition to (hetero)aryl bromide and another to activate terminal alkyne substrate, leads to productive Pd−Pd transmetalation, subsequent reductive elimination, and formation of disubstituted alkyne. This conceptually novel rational design of copper-free Sonogashira reaction enabled facile identification of the reaction conditions, suitable for the synthesis of alkyl, aryl, and heteroaryl substituted alkynes at room temperature with as low as 0.125 mol % total Pd loading. catalysis palladium Sonogashira reaction alkyne hydrocarbons copper ligands addition reactions kataliza paladij Sonogashira reakcija alkini hidrokarbonati baker ligandi adicijske reakcije true false true Angleški jezik Slovenski jezik Članek v reviji 2021-03-12 14:37:08 2021-03-12 14:37:08 2022-09-05 03:50:30 0000-00-00 00:00:00 2020 0 0 Str. 4938-4943 iss. 13 Vol. 22 2 Jul. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547:544.47:546.98 1523-7060 10.1021/acs.orglett.0c01227 14359811 1916442 RAZ_Martek_Bruno_Aleksander_2020.pdf RAZ_Martek_Bruno_Aleksander_2020.pdf 1 2905B5E6A188199C47BC879EF2FDE3C7 d8d4ccac664add78d6f86e9e0e90171f3d64fb47c9472f1bee26bc8476466f8d b3474742-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=141084 https://pubs.acs.org/doi/10.1021/acs.orglett.0c01227 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=141082 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0