20.500.12556/RUL-125367 Iron-binding and anti-fenton properties of novel amino acid-derived cyclic imide dioximes We present a novel route for the preparation of amino acid-derived cyclic imide dioxime derivatives. Readily accessible amino acids were conveniently converted to their corresponding cyclic imide dioximes in simple synthetic steps. The aim of this work was to describe and compare the iron-chelating and antioxidant properties of synthesized compounds in relation to their molecular structure, and in particular, which of those features are essential for iron(II)-chelating ability. The glutarimide dioxime moiety has been established as an iron(II)-binding motif and imparts potent anti-Fenton properties to the compounds. Compound 3 was shown to strongly suppress hydroxyl radical formation by preventing iron cycling via Fe-complexation. These findings provide insights into the structural requirements for achieving anti-Fenton activity and highlight the potential use of glutarimide dioximes as antioxidants. amino acid building block iron(II)-chelating agents cyclic imide dioxime antioxidant Fenton reaction anti-Fenton aminokisline antioksidanti Fentonova reakcija ciklični dioksimi true false true Angleški jezik Slovenski jezik Članek v reviji 2021-03-12 11:52:59 2021-03-12 11:53:00 2022-09-05 03:50:25 0000-00-00 00:00:00 2019 0 0 12 str. iss. 10, art. 473 Vol. 8 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.466:615.4:54 2076-3921 10.3390/antiox8100473 4819569 522976025 RAZ_Mravljak_Janez_2019.pdf RAZ_Mravljak_Janez_2019.pdf 1 648F8D3C7879DFA60E5E9D5F4F0FB2C7 40bdd931114e5e8780624906ab0895e5b61e5c26514fe066d888d25fb1af6d9b b2830e55-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=141062 https://www.mdpi.com/2076-3921/8/10/473 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=141061 Fakulteta za farmacijo 0 0 0