20.500.12556/RUL-124473 Pharmacokinetics of carprofen in anaesthetized pigs a preliminary study Objective To investigate the pharmacokinetics of carprofen after a single intravenous (IV) dose and multiple oral doses administered to pigs undergoing electroporation of the pancreas. Study design Prospective experimental study. Animals A group of eight female pigs weighing 31.74 ± 2.24 kg (mean ± standard deviation). Methods Carprofen 4 mg kg−1 was administered IV after placement of a central venous catheter during general anaesthesia with isoflurane. Blood samples were collected 30 seconds before and 5, 10, 20, 30 and 60 minutes and 2, 4, 6, 8, 12 and 24 hours after carprofen administration. Subsequently, the same dose of carprofen was administered orally, daily, for 6 consecutive days and blood collected at 36, 48, 60, 72, 96, 120, 144 and 168 hours after initial carprofen administration. Plasma was analysed using liquid chromatography with mass spectrometry. Standard pharmacokinetic parameters were calculated by compartmental analysis of plasma concentration–time curves. Data are presented as mean ± standard error. Results The initial plasma concentration of IV carprofen was estimated at 54.57 ± 3.92 μg mL−1 and decreased to 8.26 ± 1.07 μg mL−1 24 hours later. The plasma elimination curve showed a bi-exponential decline: a rapid distribution phase with a distribution half-life of 0.21 ± 0.03 hours and a slower elimination phase with an elimination half-life of 17.31 ± 3.78 hours. The calculated pharmacokinetic parameters were as follows: the area under the plasma concentration–time curve was 357.3 ± 16.73 μg mL−1 hour, volume of distribution was 0.28 ± 0.07 L kg−1 and plasma clearance rate was 0.19 ± 0.009 mL minute−1 kg−1. The plasma concentration of carprofen, administered orally from days 2 to 7, varied from 9.03 ± 1.87 to 11.49 ± 2.15 μg mL−1. Conclusions and clinical relevance Carprofen can be regarded as a long-acting non-steroidal anti-inflammatory drug in pigs. Carprofen pharmacokinetics swine true false true Angleški jezik Ni določen Članek v reviji 2021-01-25 12:32:10 2021-01-25 12:32:10 2022-09-04 03:59:40 0000-00-00 00:00:00 2021 0 0 Str. 35-41 no. 1 Vol. 48 2021 0000-00-00 PostprintKoncna Objavljeno NiDoloceno 0000-00-00 0000-00-00 2021-01-19 2022-01-19 636.4.09:616-089 1467-2987 10.1016/j.vaa.2020.09.006 34537987 1098874 RAZ_Bosnjak_Masa_2021.pdf RAZ_Bosnjak_Masa_2021.pdf 1 7A1141BA1C8DD03614599DFC1FB1F87B dc9637b09a03108745c09a791ee594b5d5d3438d78bd7fdb9d82cc80fa1900ab 8fa83476-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=139975 https://www.sciencedirect.com/science/article/pii/S1467298720302270?via%3Dihub članek dostopen za konzorcij UL 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=139973 Medicinska fakulteta Veterinarska fakulteta 0 0 0