20.500.12556/RUL-118708 Could sex/gender differences in ACE2 expression in the lungs contribute to the large gender disparity in the morbidity and mortality of patients infected with the SARS-CoV-2 virus? COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). Although there are no data for the lung, the expressions of RAS components in other tissues are modulated by sex hormones, androgens, and estrogens. However, there are no data on sex-specific differences in ACE2 expression. If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients. pneumonia viral corona virus infection epidemiology peptidyl-dipeptidase A androgens estrogens blood sex factors sex distribution COVID-19 virusna pljučnica corona virusna infekcija epidemiologija peptidil-dipeptidaza A androgeni estrogeni kri spolni faktorji porazdelitev spolov COVID-19 true false true Angleški jezik Slovenski jezik Članek v reviji 2020-08-31 13:09:42 2020-08-31 13:09:43 2023-05-25 08:51:02 0000-00-00 00:00:00 2020 0 0 3 str. Vol. 10, art. 327 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.24:616.9 2235-2988 10.3389/fcimb.2020.00327 20234499 523093785 RAZ_Majdic_Gregor_2020.pdf RAZ_Majdic_Gregor_2020.pdf 1 16F602C78C642B309289D8B7F07A56DD 98250cc6809943a89151a37409bac339f47160b3462059677384abe02f14fe12 9094e00c-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=139995 https://www.frontiersin.org/articles/10.3389/fcimb.2020.00327/full 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=133096 Veterinarska fakulteta 0 0 0