20.500.12556/RUL-117163 Sinteza derivatov bifenila z različnimi elektron-privlačnimi skupinami Synthesis of biphenyl derivatives having electron-withdrawing groups Sintetizirani so bili štirje novi bifenilni analogi z različnimi elektron-privlačnimi skupinami: karbonilno, 1,3-dikarbonilno, malononitrilno in oxo-piran-karbonitrilno. Spojine emitirajo svetlobo različnih valovnih dolžin, kar kaže na pomemben vpliv elektron-privlačnih skupin na optične lastnosti molekul. Produkti so bili sintetizirani s kombinacijo reakcij spajanja po Suzukiju, Claisenove in Knoevenagelove kondenzacije. Pripravljeni analogi bi bili lahko v nadaljnjih raziskavah uporabljeni kot molekulske sonde za detekcijo tau agregatov v krvi bolnikov z nevrodegenerativnimi boleznimi. In this work, I successfully synthesised four new biphenyl analogues with different electron-accepting groups: carbonyl, 1,3-dicarbonyl, malononitrile, and oxo-pyran-carbonitrile. A large difference in the wavelength of the emitted light was observed – suggesting a significant effect of electron-withdrawing groups on optical properties of molecules. The products were synthesised using a combination of Suzuki cross-coupling, Claisen, and Knoevenagel condensation reactions. The derivatives prepared in this work could be potentially used as molecular probes for the detection of tau aggregates in the blood of patients with neurodegenerative diseases. bifenilni analogi optične lastnosti molekulske sonde nevrodegenerativne bolezni reakcije spajanja biphenyl derivatives optical properties molecular probes neurodegenerative disease cross-coupling reactions true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2020-06-26 10:25:09 2020-06-26 10:25:14 2022-08-29 03:41:35 0000-00-00 00:00:00 2020 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 6321 21047811 Kulasic_Ines_-_Sinteza_derivatov_bifenila_z_razlicnimi_elektron-privlacnimi_skupinami.pdf Kulasic_Ines_-_Sinteza_derivatov_bifenila_z_razlicnimi_elektron-privlacnimi_skupinami.pdf 1 E66AD54FDCA953357ED94C2BB06C6044 40ac575a4d3b97a53bcf0e734d6d4fd9481239c15c6130c32607ebae96b7a018 1d3b62c5-a1b9-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=130965 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0