20.500.12556/RUL-116657 Health-related quality of life in dogs treated with electrochemotherapy and/or interleukin-12 gene electrotransfer The aim of this study was to evaluate the owners' perception of health-related quality of life (HRQoL) of dogs after treatment with electrochemotherapy (ECT) alone or combined with interleukin-12 gene electrotransfer (IL-12 GET) and/or surgery. The owners of 44 dogs with histologically different tumours were offered the »Cancer Treatment Form« at least one month after treatment. The owners assessed their dogs’ quality of life (QoL) after treatment as good (mean 7.4) (from 1–very poor to 10–excellent) and the general health compared with the initial diagnosis of cancer as improving (mean 3.9) (from 1–worse to 5–better). The assessment of the current QoL was better within the group of dogs treated with non-invasive treatment (ECT and/or IL-12 GET only), compared with those that received invasive treatment, where, in addition to ECT and/or IL-12 GET, surgery was performed (p < .05). The owners of dogs that achieved an objective response (OR) to the treatment assessed the QoL as significantly better compared with those whose dogs did not respond to the treatment (p < .05). The majority of the owners (86.4%) would opt for the therapy again, regardless of the financial costs. In conclusion, the results of this study demonstrate that the majority of the owners of dogs assessed their dogs’ QoL as good and felt that it improved after the treatment, especially in dogs, treated with non-invasive treatment and in those that responded to the treatment. This supports further use of ECT and IL-12 GET as suitable methods for the treatment of selected tumours in veterinary medicine. dogs electrochemotherapy gene electrotransfer health-related quality of life interleukin-12 neoplasms therapy receptors true false true Angleški jezik Ni določen Članek v reviji 2020-06-01 11:05:41 2020-06-01 11:05:42 2025-04-23 15:28:22 0000-00-00 00:00:00 2020 0 0 Str. 290–298 iss. 3 Vol. 6 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 636.09:602.6/7 2053-1095 10.1002/vms3.232 4920442 525255961 Veterinary_Medicine___Sci_-_2020_-_Milevoj_-_Health‐related_quality_of_life_in_dogs_treated_with_electrochemotherapy_and_or.pdf Veterinary_Medicine___Sci_-_2020_-_Milevoj_-_Health‐related_quality_of_life_in_dogs_treated_with_electrochemotherapy_and_or.pdf 1 D2F01CB4FDE032C35CCE7817C0B1EB11 28183db9cacbd5bed4658508ba9cdea321bdf7057255acbabfef69ed6c1ebd40 73c5fa07-1acb-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=208532 https://onlinelibrary.wiley.com/doi/10.1002/vms3.232 0 bbefb5d1-2042-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=209684 Veterinarska fakulteta 0 0 0