20.500.12556/RUL-116518 Surfaktanti v čistilnih sredstvih za telo in njihova interakcija s kožo Surfactants in body cleansers and their interaction with skin Surfaktanti (površinsko aktivne snovi) so amfifilne molekule, ki vsebujejo polarno glavo in nepolaren rep, zato so zelo dobra čistilna sredstva. Z njimi se srečujemo vsakodnevno, saj so glavna sestavina sredstev za čiščenje kože. Geli za prhanje in tekoča mila so vodne raztopine surfaktantov, v katerih so surfaktanti prisotni v obliki micel in monomerov. Ob stiku s kožo surfaktanti odstranijo sebum, znoj in umazanijo. Lahko pa interagirajo z lipidi in proteini v zgornji plasti kože (Stratum corneum), kar vodi do draženja kože. Prodrejo lahko v globlje plasti kože vse do živih kožnih celic in povzročijo kožne bolezni – iritativni kontaktni dermatitis. Obstaja več modelov prodiranja surfaktantov v kožo. Predstavila sem metode za oceno in zmanjšanje dražilnih učinkov surfaktantov, ki se pojavijo v literaturi. Slednje se lahko doseže s primerno izbiro primarnega surfaktanta in uporabo mešanic surfaktantov. Izbrane kozmetične produkte iz trgovin sem razdelila v naslednje kategorije: geli za prhanje (normalni, nežnejši, otroški), tekoča mila (za roke in za intimne predele) in micelarne vode. Namen raziskave je ugotoviti, kateri surfaktant oz. kombinacija surfaktantov je najpogostejša v posamezni kategoriji in ali med kategorijami obstajajo razlike v surfaktantni sestavi. Surfactants (surface active agents) are amphiphilic molecules which contain a polar head and a nonpolar tail, so they are very good cleansing agents. They are used on a daily basis, being a major component of skin cleansers. Shower gels and liquid soaps are aqueous solutions of surfactants, in which surfactants are present in the form of micells and monomers. When interacting with skin, surfactants remove sebum, sweat and dirt. However, they can interact with lipids and proteins of Stratum corneum, leading to skin irritation. Furthermore, they can penetrate into deeper skin layers all the way to living skin cells and cause skin diseases – irritant contact dermatitis. There are several models of surfactant penetration into skin. I presented methods for both evaluating and reducing the surfactants irritating potential that has been reported in literature. The latter can be achieved by appropriate selection of the primary surfactant and by using surfactant mixtures. In this research, a number of retail store products were divided into the following categories: shower gels (normal, gentler, baby), liquid soaps (for hands and intimate areas) and micellar waters. The purpose of the research was to determine which surfactant or combination of surfactants is the most common in each category and whether there are differences between categories based upon that. surfaktanti koža interakcije geli za prhanje tekoča mila surfactants skin interactions shower gels liquid soaps true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2020-05-26 17:31:47 2020-05-26 17:31:49 2022-08-28 03:49:11 0000-00-00 00:00:00 2020 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 6109 16928003 Knap_Mateja_-_Surfaktanti_v_cistilnih_sredstvih_za_telo_in_njihova_interakcija_s_kozo.pdf Knap_Mateja_-_Surfaktanti_v_cistilnih_sredstvih_za_telo_in_njihova_interakcija_s_kozo.pdf 1 0694744568A3140E68DC8236E3CB4D10 1cca81b2c4fe6ca4a6658b98d860ce79d4942dbcd90eb96a83b3a64ed4bc7766 f67f3cc2-a1b8-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=130138 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0