20.500.12556/RUL-115059 Sinteza organokatalizatorjev na osnovi kinuklidina Synthesis of organocatalysts based on quinuclidine Iz 3,4-dietoksiciklobut-3-en-1,2-diona (1) in 3,5-bis(trifluorometil)anilina (4) sem uspešno pripravil skvaramat 5. Sinteza analognega skvaramata 3 iz 3,4-dietoksiciklobut-3-en-1,2-diona (1) in 3,5-bis(trifluorometil)benzilamina (2) ni bila uspešna. S katalitskim hidrogeniranjem alkena 6 sem pripravil aminski gradnik 7. Iz skvaramata 5 in aminskega gradnika 8 sem uspešno pripravil organokatalizator 3-((3,5-bis(trifluorometil)fenil)amino)-4-(((S)-kinolin-4-il((1S,2S,4S,5R)-5-vinilkinuklidin-2-il)metil)amino)ciklobut-3-en-1,2-dion (9). Vse produkte sem pripravil po postopkih iz literature. Squaramate 5 was prepared from 3,4-diethoxycyclobut-3-ene-1,2-dione (1) and 3,5-bis(trifluoromethyl)aniline (4). Synthesis of the analogous squaramate 3 from 3,4-diethoxycyclobut-3-ene-1,2-dione (1) and 3,5-bis(trifluoromethyl)benzylamine (2) was not successful. Catalytic hydrogenation of alkene 6 gave the amine building block 7. Starting from squaramate 5 and amine building block 8, the desired organocatalyst 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (9) was synthesized. All the products were prepared following the literature procedures. organokatalizator kinuklidin kinolin amin organocatalyst quinuclidine quinoline amine true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2020-04-10 11:25:02 2020-04-10 11:25:04 2022-08-27 03:59:16 0000-00-00 00:00:00 2020 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 4741 1538567363 Mezek_Uros_-_Sinteza_organokatalizatorjev_na_osnovi_kinuklidina.pdf Mezek_Uros_-_Sinteza_organokatalizatorjev_na_osnovi_kinuklidina.pdf 1 0BD377E87E19ED9AF68657778DBE18D4 feaae0a7357527ac4f7ce33fa904d27965b63ec9fbab454ad8e0185278926866 5c796448-a1b8-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=127599 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0