20.500.12556/RUL-113479 Phenotypes associated with pathogenicity their expression in Arctic fungal isolates Around 85% of the environments on Earth are permanently or seasonally colder than 5 °C. Among those, the poles constitute unique biomes, which harbor a broad variety of microbial life, including an abundance of fungi. Many fungi have an outstanding ability to withstand extreme conditions and play vital ecosystem roles of decomposers as well as obligate or facultative symbionts of many other organisms. Due to their dispersal capabilities, microorganisms from cryosphere samples can be distributed around the world. Such dispersal involves both species with undefined pathogenicity and potentially pathogenic strains. Here we describe the isolation of fungal species from pristine Arctic locations in Greenland and Svalbard and the testing of the expression of characteristics usually associated with pathogenic species, such as growth at 37 °C, hemolytic ability, and susceptibility to antifungal agents. A total of 320 fungal isolates were obtained, and 24 of the most abundant and representative species were further analyzed. Species known as emerging pathogens, like Aureobasidium melanogenum, Naganishia albida, and Rhodotorula mucilaginosa, were able to grow at 37 °C, showed beta-hemolytic activity, and were intrinsically resistant to commonly used antifungals such as azoles and echinocandins. Antifungal resistance screening revealed a low susceptibility to voriconazole in N. albida and Penicillium spp. and to fluconazole in Glaciozyma watsonii and Glaciozyma-related taxon. Arctic fungi emerging pathogens thermotolerance hemolysis antifungal resistance true false true Angleški jezik Ni določen Članek v reviji 2020-01-10 08:21:09 2020-01-10 08:21:09 2022-08-25 03:56:33 0000-00-00 00:00:00 2019 0 0 15 str. iss. 12, art. 600 Vol. 7 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 579 2076-2607 10.3390/microorganisms7120600 5275471 RAZ_Perini_Laura_2019.pdf RAZ_Perini_Laura_2019.pdf 1 7082E48DD44EBE5BA780DA5E190A621F a6aa98506f4a5e83cf4eb2fffc5d46336d933fdb1675d347ddae9f4d549cf5ff 73b04430-42ee-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=150926 https://www.mdpi.com/2076-2607/7/12/600 0 6dadc1a1-42ee-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=150925 Biotehniška fakulteta Medicinska fakulteta 0 0 0