20.500.12556/RUL-110547 Sinteza fluoroforov s 4-fenilazo-anilinskim skeletom Na podlagi molekulskih sond, ki so kazale ugodne optične lastnosti za uporabo v fluorescenčni mikroskopiji in vezavne lastnosti na odlage proteina tau, je bila zasnovana spojina 4-(4-((4-(etil(2-fluoroetil)amino)fenil)diazenil)fenil)-6-metil-2-okso-2H-piran-3-karbonitril. Na podlagi literaturnih podatkov tvorb gradnikov molekule je bila začrtana sintezna pot. Ta je vključevala reakcije Claisenove kondenzacije, diazotiranja, spajanja v azo spojino, fluoriranja in Knoevelagel-ove kondenzacije. V tem delu so predstavljene sinteze spojin, ki bi lahko služile kot intermediate na poti do željene spojine. Sinteza končne spojine pod izbranimi pogoji ni bila uspešna. Based on molecular probes, that have favourable optical properties for use in fluorescence microscopy and favourable binding affinity towards protein tau aggregates 4-(4-((4-(ethyl(2-fluoroethyl)amino)phenyl)diazenyl)phenyl)-6-methyl-2-oxo-2H-pyran-3-carbonitrile was designed. Synthesis plan was chosen in accordance with literature data on the synthesis of building blocks present in the designed molecule. It included reactions of Cleisen condensation, diazotation, azo coupling, fluorination and Knoevelagel condensation. In this work, syntheses of intermediary compounds used for to obtain the final molecule are presented. The synthesis of the final compound was unsuccessful under the chosen conditions. fluorofori azo spojine Claisenova kondenzacija sinteza fluorophores azo compounds Cleisen condensation synthesis true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2019-09-16 15:17:25 2019-09-16 15:17:25 2022-08-22 03:44:27 0000-00-00 00:00:00 2019 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 6281 1538434755 Gabrovsek_Marko_-_Sinteza_fluoroforov_s_4-fenilazo-anilinskim_skeletom.pdf Gabrovsek_Marko_-_Sinteza_fluoroforov_s_4-fenilazo-anilinskim_skeletom.pdf 1 F78F144435501B1CDDE9D04FB4CFDB4D 0003ceb200114653b5b619f533d5653c5f636095e3cf7bd25f00235df3d99f03 255e95df-a1b7-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=122217 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0