20.500.12556/RUL-110547
Sinteza fluoroforov s 4-fenilazo-anilinskim skeletom
Na podlagi molekulskih sond, ki so kazale ugodne optične lastnosti za uporabo v fluorescenčni mikroskopiji in vezavne lastnosti na odlage proteina tau, je bila zasnovana spojina 4-(4-((4-(etil(2-fluoroetil)amino)fenil)diazenil)fenil)-6-metil-2-okso-2H-piran-3-karbonitril. Na podlagi literaturnih podatkov tvorb gradnikov molekule je bila začrtana sintezna pot. Ta je vključevala reakcije Claisenove kondenzacije, diazotiranja, spajanja v azo spojino, fluoriranja in Knoevelagel-ove kondenzacije. V tem delu so predstavljene sinteze spojin, ki bi lahko služile kot intermediate na poti do željene spojine. Sinteza končne spojine pod izbranimi pogoji ni bila uspešna.
Based on molecular probes, that have favourable optical properties for use in fluorescence microscopy and favourable binding affinity towards protein tau aggregates 4-(4-((4-(ethyl(2-fluoroethyl)amino)phenyl)diazenyl)phenyl)-6-methyl-2-oxo-2H-pyran-3-carbonitrile was designed. Synthesis plan was chosen in accordance with literature data on the synthesis of building blocks present in the designed molecule. It included reactions of Cleisen condensation, diazotation, azo coupling, fluorination and Knoevelagel condensation. In this work, syntheses of intermediary compounds used for to obtain the final molecule are presented. The synthesis of the final compound was unsuccessful under the chosen conditions.
fluorofori
azo spojine
Claisenova kondenzacija
sinteza
fluorophores
azo compounds
Cleisen condensation
synthesis
true
false
false
Slovenski jezik
Angleški jezik
Diplomsko delo/naloga
2019-09-16 15:17:25
2019-09-16 15:17:25
2022-08-22 03:44:27
0000-00-00 00:00:00
2019
0
0
0000-00-00
NiDoloceno
NiDoloceno
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
6281
1538434755
Gabrovsek_Marko_-_Sinteza_fluoroforov_s_4-fenilazo-anilinskim_skeletom.pdf
Gabrovsek_Marko_-_Sinteza_fluoroforov_s_4-fenilazo-anilinskim_skeletom.pdf
1
F78F144435501B1CDDE9D04FB4CFDB4D
0003ceb200114653b5b619f533d5653c5f636095e3cf7bd25f00235df3d99f03
255e95df-a1b7-11eb-a523-00155dcfd717
https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=122217
Fakulteta za kemijo in kemijsko tehnologijo
0
0
0