20.500.12556/RUL-109940 Sinteza fluoroforov s 4-feniletinil-fenilaminskim skeletom Synthesis of fluorofores with 4-phenylethynyl-phenylamine skeleton Cilj diplomske naloge je bila sinteza novih fluoroforov s 4-feniletinil-fenilaminskim skeletom, ki bi bili na podlagi svojih optičnih in vezavnih lastnosti primerni za detekcijo proteina tau in vitro kot tudi in vivo. Sinteza 4-(4-((4-(etil(2-fluoroetil)amino)fenil)etinil)fenil)-6-metil-2-okso-2H-piran-3-karbonitril je vključevala reakcijo Claisenove kondenzacije, pripajanje po Sonagashiri in fluoriranje. Uspešno je bil sintetiziran diketon 1-(4-((4-(etil(2-hidroksietil)amino)fenil)etinil)fenil)butan-1,3-dion, ki lahko služi kot izhodna spojina za pripravo želene končne spojine. The goal of this thesis was to synthesize new fluorophores with 4-phenylethynyl-phenylamine scaffold that would be suitable for detection of tau protein in vitro as well as in vivo, based on their optical and binding properties. Synthesis of 4-(4-((4-(ethyl(2-fluoroethyl)amino)fenyl)ethynyl)fenyl)-6-methyl-2-oxo-2H-pyran-3-carbonitrile included Claisen condensation, Sonagashira coupling and fluorination reaction. Diketone 1-(4-((4(ethyl(2-hydroxyethyl)amino)¬phenyl)ethynyl)¬phenyl)¬butane-1,3-dione was successfully synthesized and can serve as a starting compound for the synthesis of the desired compound. molekulska sonda organska sinteza reakcija pripajanja fluoriranje molecular probe organic synthesis coupling reaction fluorination reaction true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2019-09-10 14:30:11 2019-09-10 14:30:11 2022-08-22 03:40:38 0000-00-00 00:00:00 2019 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 6302 1538425283 Znidersic_Nika_-_Sinteza_fluoroforov_s_4-feniletinil-fenilaminskim_skeletom.pdf Znidersic_Nika_-_Sinteza_fluoroforov_s_4-feniletinil-fenilaminskim_skeletom.pdf 1 E7543665B0BB011BC151D4520E4790E0 211d7e569aa86b49fd43821762fc8831bdef003d52713e8ecfdb438e675a1797 fec4299f-a1b6-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=121545 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0