20.500.12556/RUL-109936 Aktivacija sililiranih kislinskih derivatov simvastatina za pripravo platinovih(IV) kompleksov s protitumorskim delovanjem Activation of silylated acid derivatives of simvastatin for preparation of platinum(IV) complexes with antitumor activity V okviru diplomskega dela sem simvastatin, ki je lakton, pretvorila v njegov kislinski derivat in na proste OH skupine uvedla sililne zaščitne skupine. Sintetizirala sem aktivirane kislinske derivate dekanojske kisline in simvastatina ter preverjala njihovo zmožnost tvorbe estrov s šibkimi nukleofili. Dekanojsko kislino sem uspešno pretvorila v kislinski klorid in anhidrid, kislinski derivat simvastatina pa v anhidrid. Od naštetih derivatov je le kislinski klorid dekanojske kisline tvoril ester z monosubstituiranimi derivati fenola. Kislinski derivat simvastatina sem uporabila še v reakciji kislinsko katalizirane esterifikacije, ki pa ni vodila do želenega produkta. Po literaturnem postopku mi je uspelo pripraviti Pt(IV)-acetamidato kompleks, ki bi služil kot izhoden Pt(IV) kompleks za nadaljnjo sintezo. My bachelor thesis describes the transformation of simvastatin (lactone) into its acid derivative and silylation of its hydroxyl groups. Activated derivatives of decanoic acid and simvastatin were prepared and tested in esterification reactions with soft nucleophiles. Decanoic acid was successfully transformed into acid chloride and anhydride, while only anhydride could be prepared from acid form of simvastatin. Out of all prepared activated acid derivatives only decanoic acid chloride reacted with monosubstituted phenol derivatives. Simvastatin acid derivative was tested in acid catalysed esterification but reaction did not proceed into desired product. Pt(IV)-acetamidato complex was prepared following literature procedures as a starting material for further reactions. simvastatin cisplatin dekanojska kislina kislinski kloridi anhidridi Pt(IV) kompleksi simvastatin cisplatin decanoic acid acid chlorides anhydrides Pt(IV) complexes true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2019-09-10 13:55:06 2019-09-10 13:55:07 2022-08-22 03:40:36 0000-00-00 00:00:00 2019 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 6140 1538424259 Malensek_Katja_-_Aktivacija_sililiranih_kislinskih_derivatov_simvastatina_za_pripravo_platinovih.pdf Malensek_Katja_-_Aktivacija_sililiranih_kislinskih_derivatov_simvastatina_za_pripravo_platinovih.pdf 1 9E311A0187B1B247EC8CD217DDA5B70F b43394a88c25f51e8e44e107cc292ec30c1891bde5fec3c7dca5191f94979e30 fe7ea463-a1b6-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=121540 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0