20.500.12556/RUL-109929 Priprava piridinskih derivatov diazenkarboksamida kot ligandov za koordinacijske spojine s protitumorskim delovanjem V želji razviti učinkovino s protitumorskim delovanjem smo zastavili sintezno pot, po kateri bi pripravili diazenkarboksamidni derivat s povečano topnostjo in sposobnostjo koordinacije na prehodne kovine. V eksperimentalnem delu diplomske naloge smo iz fenilizocianata in 2-hidrazinopiridina pripravili semikarbazid in iz tega z oksidacijo sintetizirali diazenkarboksamid. Iz diazenkarboksamida in BOC-zaščitenega derivata diazenkarboksamida smo z metil jodidom in dimetil karbonatom pod različnimi pogoji poskusili pripraviti N-metilpiridinijevo sol. V tem delu opisujemo pripravo, čiščenje in analize semikarbazida in diazenkarboksamida ter postopke za poskus priprave, izolacije, čiščenja in analize produkta reakcij metiliranja z uporabo analitskih tehnik, kot sta NMR in HRMS. Želenega produkta nismo dobili v nobeni izmed reakcij. With an aim to develop a compound with antitumor activity, we designed a synthetic pathway for the preparation of a diazenecarboxamide derivative with increased solubility and the ability to coordinate to transition metals. In the experimental part of diploma thesis, we prepared semicarbazide from phenyl isocyanate and 2-hydrazinopyridine and converted it into diazenecarboxamide by oxidation. From diazenecarboxamide and BOC-protected derivative of diazenecarboxamide, we attempted to prepare N-methylpyridinium salt with methyl iodide and dimethyl carbonate under various conditions. In this diploma thesis preparation, isolation, purification and analysis of semicarbazide and diazenecarboxamide is described. Attempts of preparation, isolation, purification and analysis of the products of methylation reactions are discussed. The products of the aforementioned reactions were analyzed with NMR and HRMS techniques. The product we wished to prepare was not obtained in any of the experiments. semikarbazid diazenkarboksamid metilacija piridinijeva sol semicarbazide diazenecarboxamide methylation pyridinium salt true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2019-09-10 12:45:06 2019-09-10 12:45:08 2022-08-22 03:40:33 0000-00-00 00:00:00 2019 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 6041 1538425027 Razpotnik_Veronika_-_Priprava_piridinskih_derivatov_diazenkarboksamida_kot_ligandov_za_koordinac.pdf Razpotnik_Veronika_-_Priprava_piridinskih_derivatov_diazenkarboksamida_kot_ligandov_za_koordinac.pdf 1 0FE5CBD77F0029282F10CAA6DEFE5553 eec3de2dd0a208a24da250cb427b0a589e8555834f77847f1b99325db0cae1a7 fe04f845-a1b6-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=121533 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0