20.500.12556/RUL-108327 Vrednotenje superoksid dismutazne aktivnosti izbranih spojin z aminskimi in nitroksidnimi skupinami Evaluation of superoxide dismutase activity of selected compounds with amine and nitroxide groups Radikali so izrazito reaktivne snovi, ki imajo v svoji strukturi vsaj en nesparjen elektron. V telesu nastajajo v fiziološki presnovi celice, pri sintezi hormonov in nevrotransmiterjev ter za obrambo organizma pred patogeni. Ob povečanem nastajanju in zmanjšanem odstranjevanju radikalov, pa lahko pride do radikalsko sproženih oksidacij, kar vodi do nastanka oksidativnega stresa. Celice v telesu se pred oksidativnim stresom zavarujejo z antioksidativnim sistemom, ki deluje zaščitno in zdravilno. Enega od zaščitnih mehanizmov celic predstavlja encimski antioksidant superoksid dismutaza, ki odstranjuje superoksidni anion (superoksid). Pomembnost superoksid dismutaze je vzrok za razvoj encimomimetikov - antioksidantov, ki posnemajo delovanje tega encima. Free radicals are highly reactive substances with a structure characterised by at least one unpaired electron. They are used within the body for the physiological metabolism of cells, the synthesis of hormones and neurotransmitters and as a defence against pathogens. Increased production of radicals can, however, lead to radical-induced oxidation and, consequently, to oxidative stress. Cells are protected from oxidative stress by the antioxidant system, which has preventive and curative function. One of the mechanisms for protecting cells is the enzymatic antioxidant superoxide dismutase which removes the superoxide anion. The importance of the superoxide dismutase has led to the development of enzyme mimetics – antioxidants which mimic the activities of this enzyme. oksidativni stres SOD-mimetik superoksid dismutaza superoksid nitroksid oxidative stress mimetic SOD superoxide dismutase superoxide anion nitroxide true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2019-06-28 09:28:21 2019-06-28 09:28:22 2022-08-20 03:45:48 0000-00-00 00:00:00 2019 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 67259 266.pdf 266.pdf 1 94AC891D8E195F71364F3D2B5563E3D5 b8aa4d234d84876efdcbf529b05390fb46fc91e26832fd150bad6c794c515402 9f049ecf-a1b6-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=119282 Fakulteta za farmacijo 0 0 0