20.500.12556/RUL-108115 The use of ultrasound in the crystallization process of an active pharmaceutical ingredient In this research, ultrasound was used in the crystallization process as an alternative to conventional spontaneous crystallization and seeding crystallization. The study was implemented on an active pharmaceutical ingredient ticagrelor, where the influence of ultrasound on its physical properties was evaluated. Process parameters of spontaneous crystallization, seeding crystallization and ultrasound-assisted crystallization were extensively studied while the pros and cons of each were adequately exposed. Compared to spontaneous crystallization and seeding crystallization ultrasound-assisted crystallization has significantly improved fundamental crystallization parameters: nucleation, the growth of crystals and filtration time. At the same time, the tendency of particles to agglomerate was reduced, which lead to the avoidance of energy and time-consuming process of final product deagglomeration, often problematic in conventional crystallization. In addition, different physical properties of ticagrelor were reached and evaluated, for instance, morphology, particle size distribution and different polymorphic forms. Polymorphic forms I, II and III were efficiently produced in a repeatable, robust and optimal way. Ultrasound-assisted crystallization was proved to have a beneficial effect on the crystallization process of API, even on the industrial scale, and can successfully replace spontaneous crystallization and seeding crystallization. crystallization ultrasound active pharmaceutical ingredient ticagrelor physical properties kristalizacija ultrazvok aktivna farmacevtska sestavina inhibitor ticagrelor fizikalne lastnosti true false true Angleški jezik Slovenski jezik V članku navedeno: "© 2019 Elsevier B.V. All rights reserved." Na pristajalni strani članka navedeno: "Under a Creative Commons license"; s povezavo https://creativecommons.org/licenses/by-nc-nd/4.0/. (18. 3. 2021) Na pristajalni strani članka tudi povezava "Get rights and content", kjer navedeno tudi: "This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed." (https://s100.copyright.com/AppDispatchServlet?publisherName=ELS&contentID=S1350417719306820&orderBeanReset=true, 16. 3. 2021) Članek v reviji 2019-06-18 12:01:48 2019-06-18 12:01:49 2022-08-20 03:44:38 0000-00-00 00:00:00 2019 0 0 Str. 1-10 art. 104642 Vol. 58 2019 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66.09 1350-4177 10.1016/j.ultsonch.2019.104642 1538246083 707668 RAZ_Majal_Lucija_2019.pdf RAZ_Majal_Lucija_2019.pdf 1 26663E8FA09D23471C03B821D5D9CE2B ae35eeae2504e09ecb20b10e2884430b466bcb14f4855ffe05b846bb40b808e7 a58565a7-a1bb-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=140611 https://www.sciencedirect.com/science/article/pii/S1350417719306820 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=119042 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0