20.500.12556/RUL-106641 Recent progress in the discovery and development of DNA gyrase B inhibitors New antibacterials that modulate less explored targets are needed to fight the emerging bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search. These are both type II topoisomerases that can cleave both DNA strands, and can thus alter DNA topology during replication or similar processes. Currently, there are no ATP-competitive inhibitors of these two enzymes on the market, as the only aminocoumarin representative, novobiocin, was withdrawn due to safety concerns. The search for novel ATP-competitive inhibitors is a focus of ongoing industrial and academical research. This review summarizes the recent efforts in the design, synthesis and evaluation of GyrB/ParE inhibitors. The various approaches to achieve improved antibacterial activities are described, with particular reference to Gram-negative bacteria. antibacterial ATP-competitive DNA gyrase drug discovery Gram-negative bacteria GyrB inhibitor Par topoisomerase II topoisomerase IV zaviralci giraze B topoizomeraza IV akademske raziskave true false false Angleški jezik Slovenski jezik Znanstveno delo 2019-03-09 19:36:29 2019-03-09 19:36:31 2022-08-19 03:46:36 0000-00-00 00:00:00 2018 0 0 no. 10 Vol. 10 2018 0000-00-00 PostprintKoncna Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2019-05-22 615.015.8 1756-8919 10.4155/fmc-2017-0257 4515441 3730289 RAZ_Barancokova_Michaela_i2018.pdf RAZ_Barancokova_Michaela_i2018.pdf 1 773AE33D2FCD0F7CDB8F9EF4D8F3B705 763210fdc222c9a353ebed18cbd3b789e7a5ae867cfaaa5243ec05ada92bf19a 5cee2e08-a1b6-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=117455 https://www.future-science.com/doi/pdf/10.4155/fmc-2017-0257 1 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=117435 Fakulteta za farmacijo 0 0 0