20.500.12556/RUL-106526 NAD+ as the link between oxidative stress, inflammation, caloric restriction, exercise, DNA repair, longevity, and health span Oxidative stress and decreased DNA damage repair in vertebrates increase with age also due to lowered cellular NAD+. NAD+ depletion may play a major role in the aging process at the cellular level by limiting (1) energy production, (2) DNA repair, and (3) genomic signaling. In this study, we hypothesize that it is not NAD+ as a cofactor in redox reactions and coenzyme in metabolic processes that has the ultimate role in aging, but rather the role of NAD+ in cellular signaling when used as substrate for sirtuins (SIRT1-7 in mammals) and PARPs [Poly(ADP-ribose) polymerases]. Both sirtuins and PARPs influence many transcription factors and can affect gene expression. As a signaling molecule, NAD+ is consumed in the reaction donating ADP-ribose and releasing nicotinamide (NAM) as a by-product. It seems that aging at the cellular level is associated with a decline of NAD+ and that NAD+ restoration can reverse phenotypes of aging by inducing cellular repair and stress resistance. Adequate intracellular NAD+ concentrations may be an important longevity assurance factor, while lowered cellular NAD+ concentration may negatively influence the life span. ageing NAD+ oxidative stress niacin sirtuins Poly(ADP-ribose)Polymerases degenerative disease true false true Angleški jezik Slovenski jezik Neznano 2019-03-01 12:22:56 2019-03-01 12:51:52 2022-08-19 03:46:17 0000-00-00 00:00:00 2016 0 0 Str. 406-413 no. 5 Vol. 19 2016 0000-00-00 PostprintKoncna Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2017-10-01 612.67/.68 1557-8577 10.1089/rej.2015.1767 5019243 521921049 5019243.pdf 5019243.pdf 1 EA2EEEA073084DEAB55F423157B4FCF5 f8c3141fc0e66bad59f1825d43c23985ebb7a25aca23e476879e672e4044ecc3 59c44967-a1b6-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=117320 Zdravstvena fakulteta 0 0 0