20.500.12556/RUL-102936 Izdelava cepiv. Vaccine manufacturing. Cepljenje predstavlja pomemben preventivni ukrep proti boleznim. Cepiva delujejo na različne načine, različni pa so tudi postopki izdelave. Izdelava je kritičen postopek, saj je potrebno zagotoviti ustrezne pogoje, na koncu pa dobiti cepivo, ki bo uspešno ščitilo proti boleznim in ne imelo stranskih učinkov. V cepivih lahko uporabijo žive, a oslabljene ali pa inaktivirane mikroorganizme. Imunost lahko sprožijo s konjugiranimi proteini, polisaharidi, toksoidi ali pa očiščenimi deli mikroorganizmov. Poseben način izdelave predstavlja rekombinantno cepivo. Pri tem pridobijo antigene s pomočjo ekspresijskih sistemov. Novejši pristopi, ki ji bom opisal v tem delu, obsegajo DNK in RNK cepiva. Postopki izdelav so nekoliko drugačni od »tradicionalnih« cepiv, prav tako pa tudi delovanje cepiv. Veliko raziskav poteka na temo DNK in RNK cepiv, saj so do sedaj pokazale veliko obetov. Vaccinations play an important role in preventing diseases. Vaccines work differently and manufacturing also differs from vaccine to vaccine. Manufacturing is a critical step, as certain conditions need to be fullfilled for the vaccines to successfully protect from diseases. Live, but attenuated, or inactivated microorganisms can be used in vaccines. Immunity can be triggered by conjugated proteins, polysaccharides, toxoids or subunits. Recombinant vaccines require a special kind of manufacturing. Antigens are produced with help of expression systems. Newer approaches include DNA and RNA vaccines, which will be mentioned later in this degree. Production and ways of providing immunity differ from conventional vaccines. There is a lot of ongoing research on the topic of DNA and RNA vaccines, as the early stages showed great promise. cepiva izdelava cepiv vrste cepiv tehnologije izdelave cepiv genska cepiva vaccines vaccine manufacturing vaccine types technologies for vaccine manufacturing gene vaccines true false false [U. Popelar] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2018-09-12 07:46:38 2018-09-12 07:46:39 2022-08-16 03:39:00 0000-00-00 00:00:00 2018 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.371:606:628(043.2) 155540 9057401 3924.pdf 3924.pdf 1 9015AA6E7B8266A3F46C3E85C31D4376 86e82c6a1fb8771cf3aad4569761a7d285dba6e587a97c678b3601bd66ccd2e1 aa133803-a1b5-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=113310 Biotehniška fakulteta 0 0 0