20.500.12556/RUL-102612 Vloga variacij v genih za barvo in vzorec kožuha The role of gene variations that affect coat color and patterns Udomačene živali so v primerjavi z njihovimi divjimi predniki veliko bolj raznolike v barvah in vzorcih kožuha. Razumevanje dedovanja barve dlake ni pomembno le s stališča razumevanja osnovnih znanstvenih principov, barvni vzorec kožuha je namreč pogosto povezan tudi z drugimi fenotipskimi lastnostmi. Za razumevanje pojava in dedovanja različnih barv in vzorcev kožuha moramo poznati vpliv genov, ki so vpleteni v razvoj in migracijo melanocit, sintezo pigmentov ter v znotrajcelični pigmentni transport. V diplomskem delu smo zbrali 13 genov, ki vplivajo na barvo kožuha in njihove pleiotropne učinke. Na primeru gena TYRP1 smo s pomočjo bioinformacijskih metod poiskali kandidatni genski polimorfizem za rjavo barvo kožuha pri psu in analizirali posledice spremembe v zaporedju DNA. Pri pregledu literature smo ugotovili, da pleiotropni učinki mutacij v genih za barvo in barvne vzorce kožuha še niso dobro raziskani, čeprav so lahko barvni vzorci fenotipski označevalci za nekatere bolezni ali druge fenotipske lastnosti. Characteristic of modern domesticated animals is their large coat colour variation, which is not found in any of their wild ancestors. Understanding the inheritance of coat colour is important not only from the aspect of understanding basic scientific principles, as coat colour and patterns are often associated with other phenotypic properties/ diseases. To understand the origin and inheritance of different coat colours and patterns, we must examine the effect of coat-colour-associated genes on development and migration of melanocytes, synthesis of pigments and intracellular pigment distribution. In this paper we have collected 13 genes involved in coat coloration and their pleiotropic effects. Using the bioinformatics methods, we found the TYRP1 variant associated with coat colour in dogs. We also analysed the consequences of DNA changes. When examining the literature, we discovered that knowledge on the pleiotropic effects of these mutations is often incomplete, despite the fact that coat colour patterns are sometimes a phenotypic marker for some diseases or other phenotypic traits. biotehnologija barva kožuha vpliv genov pleiotropni učinki genetske variacije biotechnology genes that affect coat colour pleiotropic effects genetic variations true false false [L. Remic] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2018-09-05 07:45:52 2018-09-05 07:45:53 2022-08-15 03:42:53 0000-00-00 00:00:00 2018 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 575.1/.2:575.8:575.112(043.2) 154643 9058937 3611.pdf 3611.pdf 1 B189CD7989C1B2135ADD46F474B4C70B aa1641b8cc492f77e3066d0cdb3c514331f7bb7f0b69e6e6c537fd8db6f66470 92c729e6-a1b5-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=112967 Biotehniška fakulteta 0 0 0