20.500.12556/RUL-101459 Regulacija pluripotentnosti v matičnih celicah. Regulation of pluripotency in stem cells Z izrazom pluripotentne matične celice označujemo nediferencirane celice, ki se lahko razvijejo v vse tri tipe zarodnih tkiv (endoderm, ektoderm in mezoderm), ne pa tudi v ekstra embrionalna tkiva. To pomeni sposobnost razvoja v več kot 200 različnih tipov celic. Njihova glavna značilnost je zmožnost neskončnega samoobnavljanja in vitro in plastičnost, saj preko celičnih delitev ne izgubijo potenciala za diferenciacijo v različne tipe tkiv. In vivo je pluripotentno stanje embrionalnih celic in je le kratko prehodno stanje v razvoju zarodka, ki nato vodi v nadaljno diferenciacijo celic in embrionalnih tkiv. Regulacija pluripotentnosti poteka na nivoju epigenetskih modifikacij, inhibicije z miRNA, različnih transkripcijskih faktorjev in majhnih molekul. Pluripotent stem cells are undifferentiated cells, which can then evolve into all three germ layers (endoderm, ectoderm and mesoderm) but not to extraembryonic tissue. This means that they can differentiate into more than 200 types of cells. Their main characteristics is the ability to self-renew in vitro and their plasticity, as they do not lose the ability to differentiate even after multiple cell divisions. In vivo, pluripotency is a short transitional phase of the embryo, that then leads to further differentiation of cells and tissues. The cells regulate their pluripotency trough epigenetic modifications, miRNA interference, various transcriptional factors and small molecules. matične celice stanja pluripotence epigenetika transkripcijski faktorji hranilna podlaga stem cells pluripotency states epigenetics transcriptional factors feeder layer true false false [M. Bole] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2018-06-06 07:45:23 2018-06-06 07:45:24 2022-08-14 03:44:38 0000-00-00 00:00:00 2018 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 602.9:611.018:591.81(043.2) 151294 8983673 2994.pdf 2994.pdf 1 334EDF1525C453B3597DB110A4DADBB3 212ce5c212b9e0a070ed6eef954da83f77653bf87e30ceeb78cbe5b0d895986a 44c92182-a1b5-11eb-a523-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=111484 Biotehniška fakulteta 0 0 0