Deuteration of six-membered N-heteroarenesRaju, Liju (Avtor) Benedetto Tiz, Davide (Avtor) Iles, Adrian (Avtor) Košmrlj, Janez (Avtor) Jansen-van Vuuren, Ross D. (Avtor) deuterationdeuteriumdeuterium-labellingisotope-labellingN-heteroareneN-heteroaromatic compoundspyridinepyrimidinepyrazinepyridazinequinolinequinazolineelectron deficiencytriazinetetrazineorganic electronicspharmaceuticalsdyesheteroaromaticsregioselectivitySix-membered N-heteroarenes (“6NHetAr”) play pivotal roles in the pharmaceutical, agrochemical, and materials science industries. In recent times, deuterium (D)-labelled 6NHetAr have demonstrated enhanced performance over their unlabelled counterparts. For example, VV116 and VX-984, approved therapeutics for the treatment of COVID-19 and cancer, and deuterated functional materials for use as ligands in catalysts and organometallic light-emitters. As interest in this field continues to grow, there is a corresponding need to develop more efficient, scalable, and sustainable approaches to deuterate 6NHetAr. In this work, we comprehensively review approaches developed for the incorporation of D into 6NHetAr, their fused counterparts, and complex compounds containing 6NHetAr. We also provide an overview of established and emerging applications for these materials.20252025-11-10 10:18:50Članek v reviji175821UDK: 547.8:546.11.027*2ISSN pri članku: 0947-6539DOI: 10.1002/chem.202502659COBISS_ID: 255671299sl