OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cellsBricelj, Aleša (Avtor) Smrdel, Lara (Avtor) Steinebach, Christian (Avtor) Sosič, Izidor (Avtor) Anderluh, Marko (Avtor) Gobec, Martina (Avtor) The O-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence O-GlcNAcylation levels in MM.1S cells.20252025-08-25 13:16:26Članek v reviji171401UDK: 615.4:54ISSN pri članku: 2046-2069DOI: 10.1039/D5RA02801ACOBISS_ID: 243315203sl