Closed-loop control of anesthesia using two-degrees-of-freedom control with a target-controlled infusion algorithmVegelj, Aleksander (Avtor) Škrjanc, Igor (Avtor) Karer, Gorazd (Avtor) closed-loop controlanesthesiabispectral index (BIS)target-controlled infusion (TCI)two-degrees-of-freedom control (2 DoF)model predictive control (MPC)STANPUMPThis article proposes a new closed-loop control method to induce and maintain a desired depth of hypnosis during total intravenous anesthesia. The method utilizes two-degreesof-freedom control, with propofol infusion rate as the input and bispectral index (BIS) as the output. A target-controlled infusion (TCI) algorithm called STANPUMP is used as the feedforward action to achieve the desired BIS response, and a feedback controller based on a Kalman filter deals with model uncertainties. Adding a TCI algorithm as the feedforward action improves the time-to-target and enhances patient safety. This is because it allows for a seamless transition to open-loop control if needed.20252025-05-08 13:44:38Članek v reviji169048UDK: 681.5ISSN pri članku: 2405-8963DOI: 10.1016/j.ifacol.2025.03.063COBISS_ID: 234806787OceCobissID: 234805251sl