2-Bromopyridines as versatile synthons for heteroarylated 2-pyridones via Ru(II)-mediated domino C–O/C–N/C–C bond formation reactionsDrev, Miha (Avtor) Brodnik, Helena (Avtor) Grošelj, Uroš (Avtor) Perdih, Franc (Avtor) Svete, Jurij (Avtor) Štefane, Bogdan (Avtor) Požgan, Franc (Avtor) ruthenium catalysisheterocyclesC-H activationpyridones2-bromopyridinesA novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)–KOPiv–Na$_2$CO$_3$ catalytic system. Unsubstituted 2-bromopyridine was successfully converted to the penta-heteroarylated 2-pyridone product using this method. Preliminary mechanistic studies revealed a possible synthetic pathway leading to the multi-heteroarylated 2-pyridone products, involving consecutive oxygen incorporation, a Buchwald–Hartwig-type reaction, and C–H bond activation.20242024-09-19 13:49:31Članek v reviji162191UDK: 547.82ISSN pri članku: 1420-3049DOI: 10.3390/molecules29184418COBISS_ID: 208047363sl