Chloroimidazolium deoxyfluorination reagent with H$_2$F$_3$$^–$ anion as a sole fluoride sourcePrinčič, Griša Grigorij (Avtor) Omahen, Blaž (Avtor) Jelen, Jan (Avtor) Gruden, Evelin (Avtor) Tavčar, Gašper (Avtor) Iskra, Jernej (Avtor) alcoholsanionsorganic acidspharmaceuticalsreagentsIn the study, we introduce an air-stable NHC-based deoxyfluorination reagent ImCl[H$_2$F$_3$], offering a promising avenue for deoxyfluorination across various substrates. Reagent efficiently fluorinates benzyl alcohols, carboxylic acids, and P(V) compounds without external fluoride sources. A mechanistic study reveals a twostep process involving benzyl chloride as an intermediate, shedding light on the two-step reaction pathway. The Hammet plot provides insights into reaction mechanisms with different substrates, enhancing our understanding of this versatile deoxyfluorination method.20242024-09-04 13:23:23Članek v reviji160778UDK: 547.539.1ISSN pri članku: 0022-3263DOI: 10.1021/acs.joc.4c00787COBISS_ID: 206205955sl