Current uncertainties and future challenges regarding NAD+ boosting strategiesPoljšak, Borut (Avtor) Kovač, Vito (Avtor) Milisav, Irina (Avtor) nicotinamide adenine dinucleotideNAD+NAD+ boostersNAD+ precursorssafetyside effectsPrecursors of nicotinamide adenine dinucleotide (NAD+), modulators of enzymes of the NAD+ biosynthesis pathways and inhibitors of NAD+ consuming enzymes, are the main boosters of NAD+. Increasing public awareness and interest in anti-ageing strategies and health-promoting lifestyles have grown the interest in the use of NAD+ boosters as dietary supplements, both in scientific circles and among the general population. Here, we discuss the current trends in NAD+ precursor usage as well as the uncertainties in dosage, timing, safety, and side effects. There are many unknowns regarding pharmacokinetics and pharmacodynamics, particularly bioavailability, metabolism, and tissue specificity of NAD+ boosters. Given the lack of long-term safety studies, there is a need for more clinical trials to determine the proper dose of NAD+ boosters and treatment duration for aging prevention and as disease therapy. Further research will also need to address the long-term consequences of increased NAD+ and the best approaches and combinations to increase NAD+ levels. The answers to the above questions will contribute to the more efficient and safer use of NAD+ boosters.20222022-08-25 09:17:18Članek v reviji138917UDK: 613.98:616-092:66.094.3.097.8ISSN pri članku: 2076-3921DOI: 10.3390/antiox11091637COBISS_ID: 119104771sl