Microwave-assisted regioselective Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acidsDolšak, Ana (Avtor) Mrgole, Kristjan (Avtor) Sova, Matej (Avtor) cross-couplingSuzukipalladiumpyrimidinessynthesismicrowave-assistedSuzuki coupling reaction has been often used for the preparation of a diverse set of substituted pyrimidines. In this study, the Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening of reaction conditions and the use of microwave irradiation led to a very efficient and straightforward synthetic procedure providing C4-substituted pyrimidines in good to excellent yields. Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings.20212022-03-09 09:28:01Članek v reviji135364UDK: 615.4:54:547ISSN pri članku: 2073-4344DOI: 10.3390/catal11040439COBISS_ID: 59092995sl