Supplementation with >Your< Iron Syrup corrects iron status in a mouse model of diet-induced iron deficiencyPirman, Tatjana (Avtor) Lenardič, Ajda (Avtor) Nemec Svete, Alenka (Avtor) Horvat, Simon (Avtor) nutritional iron deficiencyoral supplementationmice>Your< Iron SyrupFe-sulphateThe objective of this study was to compare the effects of >Your< Iron Syrup, a novel oral liquid iron-containing food supplement, with the commonly prescribed iron sulphate (Fe-sulphate) in a mouse model of diet-induced iron deficiency. Standard inbred BALB/cOlaHsd mice were fed low-iron diet for 11 weeks to induce significant decrease in blood haemoglobin and haematocrit and were then supplemented by gavage with either >Your< Iron Syrup or Fe-sulphate for two weeks. In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice. Fe-sulphate induced similar responses, except that it did not significantly increase iron serum in females and serum ferritin in both sexes. Fe-sulphate significantly increased liver-iron content which >Your< Iron Syrup did not. Transcription of Hamp and selected inflammatory genes in the liver was comparable between the two supplementation groups and with the Control diet group. Some sex-specific effects were noted, which were more pronounced and less variable in males. In conclusion, >Your< Iron Syrup was efficient, comparable and in some parameters superior to Fe-sulphate in improving iron-related parameters without inducing a response of selected liver inflammation markers in a mouse model of diet-induced iron deficiency.20212022-03-08 09:03:17Članek v reviji135325UDK: 612ISSN pri članku: 2079-7737DOI: 10.3390/biology10050357COBISS_ID: 61018627sl