Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's diseaseDgachi, Youssef (Avtor) Bautista-Aguilera, Oscar M. (Avtor) Benchekroun, Mohamed (Avtor) Martin, Hélène (Avtor) Bonet, Alexandre (Avtor) Knez, Damijan (Avtor) Godyń, Justyna (Avtor) Malawska, Barbara (Avtor) Gobec, Stanislav (Avtor) Chioua, Mourad (Avtor) Janockova, Jana (Avtor) Soukup, Ondrej (Avtor) Chabchoub, Fakher (Avtor) Marco-Contelles, José (Avtor) Ismaili, Lhassane (Avtor) Alzheimer's diseasequinazolinonesmulticomponent reactionsmultitarget-directed ligandsantioxidantscholinesterase inhibitorshepatotoxicityWe report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (IC$_{50}$ = 1.28 % 0.03 µM), good antioxidant activity, and also proved to be non-hepatotoxic on human HepG2 cell line.20162021-09-13 10:40:53Članek v reviji130298UDK: 615.2:616.894ISSN pri članku: 1420-3049DOI: 10.3390/molecules21050634COBISS_ID: 4083825sl