Parallel synthesis of 2-substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamidesČrček, Bojana (Avtor) Baškovč, Jernej (Avtor) Grošelj, Uroš (Avtor) Kočar, Drago (Avtor) Dahmann, Georg (Avtor) Stanovnik, Branko (Avtor) Svete, Jurij (Avtor) parallel synthesispyrimidines2-(heteroaryl)ethylaminesA library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1–12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic amines 18{1–12} to afford the corresponding carboxamides 10 in good overall yields and in 80–100% purity.20122021-09-03 11:51:58Članek v reviji129517UDK: 547.853.022.057ISSN pri članku: 1420-3049DOI: 10.3390/molecules17055363COBISS_ID: 35944709sl