Preliminary toxicokinetic study of BPA in lactating dairy sheep after repeated dietary and subcutaneous administrationŠturm, Sabina (Avtor) Grabnar, Iztok (Avtor) Škibin, Andrej (Avtor) Pogačnik, Milan (Avtor) Cerkvenik, Vesna (Avtor) toxicologybisphenols A - pharmacokinetics - toxicitysheepDietary intake is the predominant route of human exposure to bisphenol A and one of the important food commodities is milk. the aim of our study was to preliminarily evaluate the bisphenol A exposure and disposition in sheep milk after repeated dietary and subcutaneous administration of a relatively low dose (100 μg/kg of b. w./day) of bisphenol A to a sheep. on the basis of blood plasma sampling, milk sampling and HpLc analysis, we developed the toxicokinetic model. With the toxicokinetic model we showed that most likely only free bisphenol A passes into the mammary gland and is subsequently conjugated there. the percentage of the dose eliminated with milk was less than 0.1%, regardless of the route of bisphenol A administration. It is proven that the bisphenol A is eliminated through the milk of lactating sheep. However, the amounts excreted in the milk that were detected in this study are minimal.20202020-08-11 08:44:02Članek v reviji118010UDK: 636.3.09:615.9ISSN pri članku: 2045-2322DOI: 10.1038/s41598-020-63286-zCOBISS_ID: 5111162OceCobissID: 18727432sl