Involvement of Long Non-Coding RNAs in Triple-Negative Breast CancerStanojević, Andrea (Avtor) Kunej, Tanja (Mentor) Pajič, Tadej (Komentor) TNBClncRNATMEimmune escapemetastasisbiomarkerstherapeutic targetsThis thesis examines the role of long non-coding RNAs (lncRNAs) in the progression of triple-negative breast cancer (TNBC), with particular focus on immune escape, cell survival, and invasion and metastasis. The work is based on a review and integration of current literature, with emphasis on lncRNAs for which experimentally supported molecular mechanisms have been described. The findings show that lncRNAs can act at several levels of tumor regulation and may have either oncogenic or tumor-suppressive functions. In immune regulation, lncRNAs such as LINK-A and GATA3-AS1 promote immune escape, while LINC01198 supports anti-tumor immune recognition. In the regulation of cell survival, H19 and NEAT1 promote proliferation and resistance to apoptosis, whereas GAS5 and PTCSC3 support tumor-suppressive processes. During invasion and metastasis, MALAT1 and PCAT6 promote metastatic behavior, while LINC00921 suppresses epithelial-to-mesenchymal transition and invasion. The reviewed evidence also indicates potential clinical value of lncRNAs as prognostic and predictive biomarkers and as therapeutic targets. However, most available evidence remains preclinical, and the heterogeneity of TNBC and context-dependent functions of lncRNAs currently limit their clinical application. Further validation in larger patient cohorts and more representative experimental models is therefore required.20262026-09-09 07:16:33Diplomsko delo/naloga187063sl