Statin adherence in atherosclerotic diseaseFurlan, Tjaša (Avtor) Došenović Bonča, Petra (Avtor) Ograjenšek, Irena (Avtor) Jug, Borut (Avtor) atherosclerotic cardiovascular diseasestatinsmedication adherencepersistencesecondary preventionAims: To evaluate post-discharge statin adherence and its association with clinical outcomes after hospitalisation for atherosclerotic cardiovascular disease (ASCVD). Methods: In this nationwide Slovenian cohort, hospital, pharmacy, and vital-status data were linked for adults hospitalised with coronary artery, cerebrovascular, or peripheral artery disease between 2015 and 2022. Statin adherence was assessed as time-varying rolling 365-day proportion of days covered (PDC) and 120-day CMA7. The outcome was all-cause death or rehospitalisation for ASCVD. Results: Of 82,083 patients in the 30-day landmark cohort, 62,932 had at least one post-discharge statin dispensing. Overall, 23% had no recorded post-discharge dispensing, rising to 30% in peripheral artery disease. Higher adherence was independently associated with lower risk of the composite outcome: each 10-percentage-point increase in PDC and CMA7 was associated with a hazard ratio of 0.96 (95% CI 0.96–0.97; both p<0.001). Conclusion: Better longitudinal statin adherence was associated with lower risk of death or recurrent ASCVD hospitalisation, while substantial treatment gaps remained, particularly in peripheral artery disease.20262026-09-05 13:10:08Neznano186851slSlovenia2015-2022