On zinc(II) coordination chemistry with furosemidePodjed Rihtaršič, Nina (Avtor) Uranjek, Zarja (Avtor) Cerc Korošec, Romana (Avtor) Hrast Rambaher, Martina (Avtor) Golob, Majda (Avtor) Modec, Barbara (Avtor) furosemidequinaldinatezinc(II)coordination compoundspolymercrystal structureantibacterial activityIn continuation of our studies on zinc(II) coordination chemistry, reactions between the zinc(II) starting material and furosemide were investigated. Furosemide, a well-known pharmaceutical, contains functional groups which could serve as donors in coordination with metal ions. Reactions between zinc oxide or chloride and furosemide in aqueous ammonia solution yielded a mononuclear complex, [Zn(NH$_3$)$_2$(fur)$_2$] (1), where fur$^−$ stands for deprotonated furosemide. Unfortunately, some reactions produced mixtures of the desired metal complex 1 and by-product, ammonium salt NH$_4$fur (2). To further explore the coordination chemistry of furosemide, quinaldinate (an anion of quinoline-2-carboxylic acid, abbreviated as quin$^−$) was introduced into the reaction system, resulting in the formation of a coordination polymer, [Zn$_3$(quin)$_4$(fur)$_2$]$_n$·2nCH$_3$OH (3). 1 and 3 were evaluated for their antibacterial properties against Gram-positive and Gram-negative bacteria. Notably, compound 3 exhibited moderate antibacterial activity against Staphylococcus epidermidis, representing a promising starting point for the preparation of potential antibacterial zinc(II) complexes.20252025-06-04 12:17:52Članek v reviji169567sl