The diagnostic accuracy of radiographic cardiac indices in the assessment of cardiomegaly and left atrial enlargement in rat with dilated cardiomyopathy: and experimental studyKaya, Mahir (Avtor) Çetinkaya, Mehmet Alper (Avtor) dilated cardiomyopathydoxorubicinratThe purpose of this study was to determine the diagnostic value of the ver-tebral heart score (VHS), radiographic left atrial dimension (RLAD), and vertebral left atrial size (VLAS) in the radiographic evaluation of doxorubicin-induced dilated cardio-myopathy (DCM) in rats. The animals were allocated into two experimental groups, a DCM group (n=100), which received weekly injections of doxorubicin (2 mg/kg per dose intraperitoneally [ip]) over nine weeks, and a control group (n=18) receiving an appropri-ate volume of 0.9% saline ip. Radiographic cardiac indices (VHS, RLAD, VLAS) were measured two weeks after the final injection, and cardiac morphological parameters (heart weight [HW], heart weight:body weight ratio [HBW], and heart weight:tibial length ratio [HTL]) were determined after sacrifice in all surviving rats (17 control and 54 DCM). Correlations were calculated between the indices and parameters, as well as their sen-sitivity and specificity in detecting cardiomegaly and left atrial enlargement (LAE) with the three classifiers (HW≤0.96 g, HBW≤235, and HTL≤201). A powerful negative correla-tion was observed between the indices and parameters (rs≥-0.711, P<0.001). Area under the curve values were 0.989 for RL-VHS, 0.992 for DV-VHS, 0.971 for RLAD, and 0.948 for VLAS. The sensitivity and specificity of these indices in detecting cardiomegaly and LAE at the optimal cut-off values were 94.4% and 100%, respectively, at 8.8 vertebrae (v) for RL-VHS and DV-VHS, 96.3% and 94.1% at 1.4v for RLAD, and 94.4% and 88.2% at 2.1v for VLAS. Radiographic cardiac indices offer an accurate and repeatable method for predicting cardiomegaly and LAE in rats with DCM.20232024-04-23 12:57:45Članek v reviji155882sl