Fetal death from SARS-CoV-2 mediated acute placental failureKosič, Nadja (Avtor) Luzar, Boštjan (Avtor) Pečlin, Polona (Avtor) Druškovič, Mirjam (Avtor) Resman Rus, Katarina (Avtor) Avšič-Županc, Tatjana (Avtor) Premru-Sršen, Tanja (Avtor) Covid-19Delta variantfetal deathearly embryo implantationSARS-CoV-2placentaIntroduction: We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure. Methods: Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus. Results: Histologic changes in the placenta correlate with SARS-CoV-2 infection. Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2. Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant. Discussion: Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive. It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. Most of the cases described with fetal death occurred in the third trimester.20232023-08-28 13:06:15Članek v reviji148646sl