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<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="https://repozitorij.uni-lj.si/IzpisGradiva.php?id=144285"><dc:title>The central role of the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases</dc:title><dc:creator>Poljšak,	Borut	(Avtor)
	</dc:creator><dc:creator>Kovač,	Vito	(Avtor)
	</dc:creator><dc:creator>Špalj,	Stjepan	(Avtor)
	</dc:creator><dc:creator>Milisav,	Irina	(Avtor)
	</dc:creator><dc:subject>NAD+ precursors</dc:subject><dc:subject>NAD+ levels</dc:subject><dc:subject>sirtuin</dc:subject><dc:subject>PARP</dc:subject><dc:description>The molecule NAD+ is a coenzyme for enzymes catalyzing cellular redox reactions in several metabolic pathways, encompassing glycolysis, TCA cycle, and oxidative phosphorylation, and is a substrate for NAD+-dependent enzymes. In addition to a hydride and electron transfer in redox reactions, NAD+ is a substrate for sirtuins and poly(adenosine diphosphate–ribose) polymerases and even moderate decreases in its cellular concentrations modify signaling of NAD+-consuming enzymes. Age-related reduction in cellular NAD+ concentrations results in metabolic and aging-associated disorders, while the consequences of increased NAD+ production or decreased degradation seem beneficial. This article reviews the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases and discusses the strategies of NAD+ modulation for healthy aging and longevity.</dc:description><dc:date>2023</dc:date><dc:date>2023-02-10 14:10:45</dc:date><dc:type>Članek v reviji</dc:type><dc:identifier>144285</dc:identifier><dc:language>sl</dc:language></rdf:Description></rdf:RDF>