Conformationally driven Ru(II)-catalyzed multiple ortho-C-H bond activation in diphenylpyrazine derivatives in waterHrovat, Sara (Avtor) Drev, Miha (Avtor) Grošelj, Uroš (Avtor) Perdih, Franc (Avtor) Svete, Jurij (Avtor) Štefane, Bogdan (Avtor) Požgan, Franc (Avtor) ruthenium catalystsheterocyclesgreen chemistrymicrowavedirect arylationRu(II)/carboxylate/PPh$_3$ catalyst system enabled the preparation of highly conjugated pyrazine derivatives in water under microwave irradiation. Both nitrogen atoms efficiently dictated cleavage of the ortho-C–H bonds in both benzene rings of 2,3-diphenylpyrazine substrates through chelation assistance. In conformationally more flexible diphenyldihydropyrazine 1, the arylation of four ortho-C–H bonds was possible, while in the aromatic analog 2, the triarylation was the limit.20202021-12-13 14:07:01Članek v reviji133746sl